Our current vacancies are listed below. For further details about each job, and to apply, you will need to follow the link to the King’s College London HireWire job board.

Available Openings

Operations Assistant

Salary: £27,994 - £31,053, inclusive of London Allowance

Contract Type: Fixed term for 24 months, full time

Application closing date:  1st July 2019

Research division: Department of Twin Research & Genetic Epidemiology

Role description:

We’re is looking to appoint a highly efficient, well organised Operations Assistant to support administrative duties in a world class clinical research group and support the Executive Director and the TwinsUK resource. The post is based at St. Thomas’ Hospital but with close links with other research departments within King’s as well as outside Research Organisations.

The post holder will be required to work closely with the Executive Director as well as other managerial staff in supporting processes involved with the TwinsUK resource. The post holder will be responsible for providing comprehensive, high quality and efficient administrative support around HR processes, financial support and procurement, website updates and routine departmental duties, arranging conference meetings and events for research activities and twin participant engagement, media and dissemination and activities relating to internal and external collaborations, running reports and financial support for departmental ordering and invoice processing, petty cash management and responsible for departmental Health and Safety inductions and H & S audit and inspections for the Department. This is a varied role and would suit someone looking for a career in administration within a university and also within a clinical research facility.

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Research Associate: Twins Genomic Analyst

Research division: Department of Twin Research & Genetic Epidemiology

Contract type: Fixed term contract for 24 months

Salary:  £37,412 to £44,015 per annum, inclusive of £3,223 per annum London Allowance.

Application closing date:  14th July 2019

Project description:

We are looking for someone with initiative, creativity and drive who is particularly interested in investigating the connection between physical and mental health. The post holder will have a unique role across two internationally renowned twin cohorts, both placed at King’s College London – TwinsUK and the Twins Early Development Study (TEDS). Together these cohorts are the largest cohort in the UK and some of the most deeply phenotyped and genotyped in the world.

High levels of co-morbidity between long-term physical and mental illness and recent mechanistic insights highlight the importance of greater integration of mental and physical health research. Twin studies offer a multidimensional approach, availing health research with a portfolio of methods to observe effects of both genes and environment on development and interaction of physical and mental health conditions. The TEDS cohort, comprising twins followed from birth into their twenties has focussed on psychological and social aspects of development, while TwinsUK has focused on physical and mental health in ageing. This post results from an exciting new collaboration between these cohorts and will cross-fertilise the strengths of both. Using a twin-based approach, the post holder will have the opportunity to engage in new research spanning across the adult lifespan on the body-mind interface, availing themselves of the extensive genetic, epigenetic, metabolomic, immune-phenotyping and other multi-omic datasets held by the cohorts.

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Metabolites, microbiome and cardiometabolic health PhD studentship

Research division: Department of Twin Research & Genetic Epidemiology, Division of Genetics & Molecular Medicine

First supervisor: Dr Cristina Menni

Second supervisor: Dr Ana M Valdes

Third supervisor: Prof Tim D Spector

Number of studentships: 1

Eligibility: Home/EU and International applicants welcome – see application details below

Start date:  1st October 2019

Application closing date:  Until a suitable applicant has been found

Project title:  Computational methods to explore the relationship between gut microbes, metabolites and human health

Project description:

Metabolomics and the gut microbiome are intricately involved in susceptibility and potentially monitoring of metabolic diseases. Moreover, there is increasing evidence that metabolites produced by the gut, such as branch chain amino acids, could be responsible for several metabolic conditions including insulin resistance, diabetes and obesity, thus mediating microbial effects on human health.  The faecal metabolome allows us to measure these metabolites directly, instead of assaying microbial output indirectly, e.g. by 16S or metagenome sequencing, thus providing a functional readout of the gut microbiome. Indeed, we have recently shown that while the faecal metabolome is moderately influenced by host genetics, it largely reflects microbial composition and significantly correlates with visceral fat. The objective of this PhD studentship is to identify the biochemical signature of  human health in the faecal metabolome and to determine its links with diet, the gut-microbiome and host genetics. In order to reverse or prevent chronic disease, it is essential to understand how this is linked to diet and the gut microbiome offers a unique target for intervention. This is a totally novel proposal and we are the first group in the world to use faecal metabolites as health indicators. The ultimate goal of such an endeavour is to increase health-span, understanding how the molecules produced by microbes influence our health is crucial to this.

Seeking highly motivated early career researchers with a strong statistical/mathematical/bio-informatics background for a PhD studentship in human metabolomics/microbiome at the Department of Twin Research & Genetic Epidemiology, King’s College London. The Department has close links with Divisional and other Research Departments within King’s College, as well as many external Research Organisations.

The TwinsUK is probably the most intensively studied group in the world with a wide range of omic technologies already measured. Our group includes over 60 researchers and produces over 70 papers per year in high impact factor journals including Nature, Cell and Nature Genetics and are ranked in the world top 1% of cited scientists.

The successful candidates should have at least a BSc or equivalent in the areas of bio-informatics, statistics or mathematical sciences. The project’s main focus will be on quantitative analyses of microbiome and metabolites and will involve statistical analyses. The position will be based at King’s College London on the St Thomas’ Campus.

Application details

The Studentship is open to UK & EU candidates. The funding also covers tuition fees at the EU (Home) rate. Applications from outside the EU are welcome provided candidates can source funding to cover the overseas fees.

Informal enquiries can be made in the first instance to Dr Cristina Menni KCL cristina.menni@kcl.ac.uk or to Dr Ana M Valdes ana.valdes@nottingham.ac.uk. To apply, please send to cristina.menni@kcl.ac.uk your CV, details of two academic referees and a supporting statement outlining why you are applying.

Metabolites, microbiome, diet and cardiometabolic health PhD studentship

Research division: Department of Twin Research & Genetic Epidemiology, Division of Genetics & Molecular Medicine

First supervisor: Dr Cristina Menni

Second supervisor: Dr Sarah Berry

Number of studentships: 1

Eligibility: Home/EU and International applicants welcome – see application details below

Start date:  1st October 2019

Application closing date:  Until a suitable applicant has been found

Project title:  Influence of the gut microbiome on inter-individual differences in blood pressure at fasting and in response to a combined glycaemic and lipaemic test meal challenge

Project description:

Hypertension is a major cause of cardiovascular morbidity and mortality in the UK. Animal and small human studies suggest that the gut microbiota and its metabolites act on downstream cellular targets to prevent/contribute to the pathogenesis of hypertension. The gut microbiota composition is linked to various disease states and is modifiable by dietary and therapeutic interventions. In humans, we recently reported a correlation between gut microbiota composition and arterial stiffness in women, which is minimally mediated by metabolic syndrome parameters and c-reactive protein.  Importantly post-prandial increases in BP have been shown to be a marker of arteriosclerosis and a recent study by Zeevi and collaborators found high interpersonal variability in the post-meal glucose response to identical meals which was related to microbiome composition. In light of the above, we hypothesise that the gut microbiome also affects BP post-prandial response partly mediated by its metabolites. This PhD will investigate the relationship between the gut microbiome and its metabolites, diet, and continuous ambulatory BP by using the most characterised sample available to date. It will characterise bacterial species and pathways involved in fasting and postprandial blood pressure integrating faecal metabolomics information, and seek to understand the interaction with diet.

Seeking highly motivated early career researchers with a strong statistical/mathematical/bio-informatics background for a PhD studentship in human metabolomics/microbiome at the Department of Twin Research & Genetic Epidemiology, King’s College London. The Department has close links with Divisional and other Research Departments within King’s College, as well as many external Research Organisations.

The TwinsUK is probably the most intensively studied group in the world with a wide range of omic technologies already measured (www.twinsuk.ac.uk). Our group includes over 60 researchers and produces over 70 papers per year in high impact factor journals including Nature, Cell and Nature Genetics and are ranked in the world top 1% of cited scientists.

The researcher would also work closely with the Department of Nutritional Sciences (DNS), King’s College London. The DNS is a world leading nutritional sciences research department with specialist research facilities for running human dietary intervention studies and specialised laboratory analysis.

The successful candidates should have at least a BSc or equivalent in the areas of bio-informatics, statistics or mathematical sciences. A background knowledge of nutrition and dietary assessment is desirable. The project’s main focus will be on quantitative analyses of microbiome, metabolites, ambulatory blood pressure and diet and will involve statistical analyses. The position will be based at King’s College London on the St Thomas’ Campus.

Application details

The Studentship is open to UK & EU candidates. The funding also covers tuition fees at the EU (Home) rate. Applications from outside the EU are welcome provided candidates can source funding to cover the overseas fees.

Informal enquiries can be made in the first instance to Dr Cristina Menni KCL cristina.menni@kcl.ac.uk or to Dr Sarah Berry sarah.berry@kcl.ac.uk. To apply, please send to cristina.menni@kcl.ac.uk your CV, details of two academic referees and a supporting statement outlining why you are applying.

 

Internships

We are able to take on interns who are looking to gain experience in the following areas:

  • Data entry
  • Data cleaning (minimum six weeks)
  • Routine sample processing at the laboratory
  • IT support
  • General administration

If you are interested in applying for an internship, please send your CV along with a reference confirming your current area of study or research and your progress from your current tutor or employer to victoria.vazquez[at]kcl.ac.uk. Please include the referee’s contact details.

Your application should also indicate your preferred area of work, when you would like to start, how long you would like to work with us (minimum of one month), how many days or hours a week you can contribute.