TwinsUK Launches New Fat Biopsy Study with First Twin Pair
13th February 2025 – by Aaruthy Suthahar
We have taken an exciting step forward in our mission to advance health research with the launch of the AdiProPlus Biopsies study. This study aims to uncover the role of fat tissue – known as adipose tissue – in the development of metabolic diseases such as type 2 diabetes, cardiovascular disease, and age-related health conditions. We recently had our first twin pair come in to participate in the study, marking an important milestone in this research.
Understanding the Role of Fat in Metabolic and Age-Related Diseases
Adipose tissue plays a critical role in regulating metabolic processes in the body, yet the molecular signals it sends and its genetic regulation remain poorly understood. By collecting small skin and fat tissue samples through a procedure called a biopsy, researchers hope to gain invaluable insights into how genes influence changes in fat tissue and how these changes contribute to the development of conditions like type 2 diabetes, cardiovascular disease, and ageing-related health complications.
Professor Kerrin Small explained:
“Our goal is to deepen our understanding of adipose tissue and its links to conditions like type 2 diabetes, cardiovascular disease, and ageing. This knowledge could eventually lead to better prevention and treatment strategies for a range of metabolic and age-related diseases.”
What the Study Involves
Participants undergo a careful screening process to ensure they meet the study’s safety criteria. Once recruited, participants will visit our clinic, complete questionnaires, and engage in a discussion about the procedure with our clinic team.
The biopsy itself is quick and minimally invasive, involving the collection of an 8mm circular sample of skin and fat tissue from the lower abdomen. Participants can also opt to provide an additional sample from the gluteus area. The procedure is performed under local anaesthetic, and participants are provided with aftercare instructions and options for suture removal either through their GP or at the TwinsUK clinic.
First Twin Pair’s Experience
The first twin pair to take part in the study shared their thoughts about being part of TwinsUK.
“We’ve always been interested in experimental science, and when we heard about the biopsy study, we were keen to sign up and learn more about the tests and results. This felt like a natural next step for us. The ageing aspect of TwinsUK that twins are participating in is incredibly valuable – not just for twins, but for the wider population – and we want to contribute in any way we can.”
The twins described the biopsy as a smooth and straightforward process.
“Everybody has been brilliant – they explained everything clearly, which helped us understand what to expect. They were also incredibly supportive, allowing us to go at a pace that suited us, which was lovely. The process was easy, painless, and, most importantly, for a great cause – advancing research.”